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Thyroid peroxidase antibody

定义

Thyroid peroxidase is a type of protein (called an enzyme) that cells in the thyroid gland use to make thyroid hormone. If these enzymes leak out into the bloodstream (as when thyroid cells are damaged) the immune system makes 抗体 对抗这些蛋白质. The thyroid peroxidase antibody test measures these 抗体 in the blood.

选择的名字

Thyroid antimicrosomal antibody; Antimicrosomal antibody; Microsomal antibody; Antithyroid microsomal antibody; TPOAb; Anti-TPO antibody

如何执行测试

A 血液样本 是必要的.

考试的感觉如何

When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. 这很快就会消失.

为什么要进行测试

This test is done to confirm the cause of thyroid problems, including 桥本甲状腺炎.

The test is also used to find out if an immune or 自身免疫性疾病 正在损害甲状腺.

正常的结果

A negative test means the result is normal.

Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or may test different specimens. Talk to your health care provider about the meaning of your specific test results.

异常结果意味着什么

A positive test may be due to:

  • Granulomatous or subacute thyroiditis (an immune reaction of the thyroid gland that often follows an upper respiratory infection)
  • 桥本甲状腺炎 (a reaction of the immune system against the thyroid gland)

High levels of these 抗体 have also been linked with an increased risk of:

  • 流产
  • 子痫前期 (high blood pressure and protein in the urine after the 20th week of pregnancy)
  • 早产
  • 体外受精 失败

Important: A positive result does not always mean that you have a thyroid condition or that you need treatment for your thyroid. A positive result may mean that you have a higher chance of developing thyroid disease in the future. This is often associated with a family history of thyroid disease.

Antithyroid microsomal 抗体 may be seen in your blood if you have other autoimmune conditions, 包括:

  • 自身免疫性溶血性贫血
  • 自身免疫性肝炎
  • 自身免疫性肾上腺疾病
  • 类风湿性关节炎
  • 干燥综合症
  • Systemic lupus erythematosus

风险

There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Obtaining a 血液样本 from some people may be more difficult than from others.

Other risks associated with having blood drawn are slight, but may include:

  • 大出血
  • Fainting or feeling lightheaded
  • Multiple punctures to locate veins
  • Hematoma (blood buildup under the skin)
  • Infection (a slight risk any time the skin is broken)

参考文献

张爱华,王志强. Endocrine disturbances affecting reproduction. In: Strauss JF, Barbieri RL, eds. 日元 & Jaffe's Reproductive Endocrinology. 8日艾德. Philadelphia, PA: Elsevier; 2019:chap 24.

陈国强,张国强. Thyroid peroxidase (TPO, antimicrosomal antibody, antithyroid microsomal antibody) antibody - blood. In: 陈国强,张国强, eds. Laboratory Tests and Diagnostic Procedures. 6日艾德. St Louis, MO: Elsevier Saunders; 2013:1080-1081.

Guber HA, Oprea M, Russell YX. Evaluation of endocrine function. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24日艾德. Philadelphia, PA: Elsevier; 2022:chap 25.

Salvatore D, Cohen R, Kopp PA, Larsen PR. Thyroid pathophysiology and diagnostic evaluation. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14日艾德. Philadelphia, PA: Elsevier; 2020:chap 11.

Weiss RE, Refetoff S. 甲状腺功能检查. In: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Adult and Pediatric. 7日艾德. Philadelphia, PA: Elsevier Saunders; 2016:chap 78.

审核日期: 01/09/2022

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A开发的信息.D.A.M.公司. regarding tests and test results may not directly correspond with information provided by 加州大学旧金山分校健康. Please discuss with your doctor any questions or concerns you may have.

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